Dr. Shi is a molecular biologist and her research focused on the cardioprotective effects of drug, hypothermia and stem cell on myocardial infarction. She has observed that a mitochondrial-targeting peptide (Bendavia) improved expression of mitochondrial energy metabolism genes and prevented myocardial matrix remodeling in the noninfarcted border zone of infarcted hearts and she presented her work in American Heart Association Scientific Sessions and Experimental Biology 2014. Jianru is now doing the PCR array to investigate the underlying mechanisms of the protective role of hypothermia on myocardial infarction.
Dr. Shi received her MD from the Henan Medical University in 1996 and her PhD in cardiovascular pathology from the Peking Union Medical College, Beijing, China in 2004. Dr. Shi pursued her postdoctoral studies at Harvard Medical School & Brigham and Women’s Hospital, Boston, USA in 2005. She obtained training in redox regulation and inflammation in cardiovascular disease during her graduate studies. After graduation, she worked at Brigham and Women’s Hospital to investigate the molecular mechanisms underlying the development of primary amyloid cardiomyopathy and the role of inflammation in metabolic regulation within the cardiovascular system. Her interests in translational research led her to join Dr. Kloner group in 2012 to study the mechanisms of cardioprotection.