Neurosciences, Research Scientist, Electrophysiology
Xianghong Arakaki MD, PhD
Dr. Arakaki luckily joined HMRI with Dr. Michael Harrington after her PhD in 2007, led by her interests in neurophysiology and clinical disease. Xianghong received her MD from the Medical College of Tongji University in 1998 and her MS in Neurobiology from the Medical Center of Fudan University in 2001 in Shanghai, China. Xianghong got her PhD in Neuroscience from the Dept. of Anatomy & Neurobiology of the University of Tennessee Health Science Center in Memphis, TN.
At HMRI since September 2007, Xianghong has developed great interest in migraine research. She improved her skills in electrophysiology and molecular biology in migraine research and in collaboration with her colleagues. Specifically, she has cultured primary rat hippocampal pyramidal cells and carried out patch clamp studies to provide supportive evidence for Dr. Harrington’s sodium theory of migraine. NEURON simulation together with Dr. Harrington’s MRI sodium imaging gave further proof for sodium-related neuronal hyper-excitability in migraine. Brainstem auditory evoked potential (BAEP) studies in rat migraine model fuel her passion for translational research between animal models and humans.
Xianghong is now exploring in vivo neurophysiological studies, including evoked potentials (EPs), event-related potentials (ERPs), electroencephalography (EEG), and magnetoencephalography (MEG) (together with Thao Tran and Dave Strickland), to investigate the underlying mechanisms of migraine, mild traumatic brain injury (mTBI), and other conditions.
The goal of her research would be to develop and apply non-invasive neurophysiological skills to clinic neurological conditions, including migraine, mTBI, and Alzheimer’s disease.