Student Research Projects

List of Recent Student Research Projects

Cancer Genetics:

  • MicroRNA Expression Profiling in Colorectal Cancer
  • Sebaceous Adenoma: DNA Sequencing Case Study
  • Analysis of a rare APC gene variant at the mRNA level

 

Liver Research:

  • Clinical Outcomes in Patients with Hepatitis B Virus and Hepatocellular Carcinoma
  • Hepatitis B treatment algorithm including screening for viral mutants
  • Demographics of Asian Americans with Hepatitis B
  • Clinical course of hepatocellular carcinoma in Hepatitis C patients treated with interferon
  • Analysis of clinical progression in patients with normal ALT chronic Hepatitis C

 

Magnetic Resonance Spectroscopy:

  • MRS in Glucose Transporter Deficiency Syndrome
  • Magnetic Resonance Imaging Intelligence: A Preliminary Study
  • The effect of aging on hippocampal volume and cortical MRS signals
  • Diffusion Tensor Imaging in hydrocephalus patients
  • Development of polarizer for hyperpolarization of MR agents
  • Imaging of strain in carotid arteries using DENSE MRI
  • Measurement of atherosclerotic plaque using hyperpolarization technique
  • Right ventricular function in patients with dilated cardiomyopathy
  • Cardiac MRI analysis of ejection fraction
  • Hyperpolarization in vivo
  • Identifying mild cognitive impairment and Alzheimer’s disease using MRS and quantitative MRI
  • Metabolic evidence of glial abnormalities during primary HIV infection

 

Molecular Neurology:

  • Endocannabinoids in Alzheimer’s Disease
  • Sphingomyelin and Sphingolipid in Alzheimer’s Disease
  • CSF glycerophospholipids and phospholipase A2 in Alzheimer’s Disease
  • Noninvasive Measurement of Oxidative Stress in Alzheimer’s Patients
  • Apolipoprotein A-1 in Alzheimer’s Disease
  • Carnonsine pathway in Alzheimer’s Disease
  • CSF biomarkers in Alzheimer’s disease
  • Bioinformatic analysis of lipids in CSF from healthy people and Alzheimer’s patients
  • Comparison of daily nutrient estimates among men and women in an Alzheimer’s study disease
  • Membrane-bound particles in the cerebrospinal fluid in Alzheimer’s disease
  • Detection of myeloperoxidase and cholesterol in cerebrospinal fluid in neurological diseases
  • Clinical features of migraine, stress and endocannabinoid biochemistry
  • Capillary sodium regulation in the ciliary body and retina in a rat migraine model
  • Auditory neurophysiology of migraine
  • The dura mater of a rat migraine model at the capillary endothelial cell level
  • Brain capillary endothelial cell Na+ pumps in the rat migraine model
  • Endocannabinoids in migraine
  • Endogenous steroid glycosides in Na+/K+-ATPase activity in migraine
  • Detection of phospholipases in cerebrospinal fluid during migraine
  • Alpha and beta CGRP in CSF of migrainers
  • CSF and body fluids of migraineurs in Ojai Headache clinic
  • Circadian rhythms of cation concentrations in human saliva and urine
  • Compositional Glycerophospholipid Changes in a Ketogenic SN1A KO Epilepsy Model
  • Needles in the migraine haystack: Cerebrospinal Fluid biomarkers
  • Composition of nanostructures in the cerebrospinal fluid of hydrocephalus patients
  • Primary cultures of rats’ hippocampal astrocytes as part of construction for an artificial blood brain barrier for migraine studies
  • Effect of NKAT regulators on sodium concentration of the brain
  • c-Fos and Western Blot detection of Sodium-Potassium ATPase in α-2 Heterozygous Mice
  • Cyclic Vomiting Syndrome: A Migraine Comorbidity

 

Molecular Pathology:

  • Expression of Bcl2 and HIF-1α in breast cancer
  • Jagged1, a potential marker for prostate and cervical cancers
  • GST Pi and prostate cancer
  • Cytoplasmic and nuclear PTEN as a prognostic marker for prostate cancer
  • Expression of Hepatocyte Growth Factor in human breast cancer
  • Expression of chemokine receptor CXCR4 and its ligand in breast cancer
  • Expression of fibroblast immunomarkers in breast cancer

 

Neural Engineering:

  • Non-invasive Measurement of Glucose Concentration using Millimeter Waves
  • Tracking motion of rat whiskers from HD video
  • Use of modulated laser pulses for activation of light-sensitive proteins in cortex
  • Device for detection and treatment of obstructive sleep apnea
  • Image analysis of electrode locations and analysis of neuronal activity in the spinal cord
  • 3D image quantification of tissue response to intracortical neural implants
  • Comparing Tissue Response to Bimorphic, Silicon, and PLGA Probes within the Brain
  • Characterization of degradation of PLGA probes in phosphate buffered saline
  • Filament tracing for quantifying glial cells in inflamed cortical tissue
  • Electrophoretic Approach to Immunostaining Neural Tissue Sections
  • Finite element modeling of the insertion stress of polymer probes
  • High-throughput synchronous Electrochemical Impedance Spectroscopy for neural interfaces
  • The cochlear nucleus auditory prosthesis: PST histogram analysis
  • Quantification of tissue response to a novel bimorphic neural probe
  • High-throughput testing of corrosion in implantable electrodes

 

Tissue Engineering:

  • Hydrogels from human placenta and umbilical cord

 

Colorectal Research:

  • MR defecography and 3-D anorectal manometry  in obstructive defecation

 

Business Office:

  • Role of administration in advancing medical research

 

For more information on the HMRI Undergraduate/Graduate Program, please contact:
Dr. Noah Gross, Co-Chairman, HMRI Undergraduate/Graduate Program
(626) 795-4343 or ngross@hmri.org; or

 

Dr. Alfred Fonteh, Co-Chairman, HMRI Undergraduate/Graduate Program
(626) 795-4343 or afonteh@hmri.org

 

Huntington Medical Research Institutes
99 N. El Molino Ave.
Pasadena, California 91101