Title: Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease
Date: December 10, 2019
In collaboration with Doheny Eye Institute, UCLA, and Italian colleagues, HMRI’s Neurosciences department under Dr. Michael Harrington studied the functions of specialized cells (mRGC) in the retina. Cognitively healthy Brain Aging study participants with spinal fluid chemistry that predicts higher risk for Alzheimer’s disease (AD) had pupil responses, sleep, and circadian rhythms that were different from those at lower risk with good chemistry. These data suggest that mRGC cells reflect AD pathology before symptoms have started, and may help identify early AD.