Title: ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes
Date: November 27, 2019
Recent publications have reported that frequent use of gadolinium, widely employed to examine brain blood barrier leakage, can get deposited in the brain, raising the question that it may adversely affect the brain. We found that 52 HMRI and USC older research participants had no evidence of retained gadolinium 19-28 months after receiving the agent, in spite of having leaky capillaries. This is reassuring for further use of this technique to investigate the important brain capillary leaks that arise in early Alzheimer’s disease.