Title: Potential for stem cell-derived biologic pumps for cardiovascular and other medical therapies
Date: July 17, 2019
When the heart is injured, there may be a need to improve blood flow by developing ventricular assist devices that help move blood forward. This paper reviews our previous experience with utilizing immature heart cells implanted not into the heart but into blood vessel walls, such as the aorta or vena cava, to provide auxiliary pumps for blood flow to the organs of the body. We previously showed that immature heart cells could survive, differentiate, grow and contract when implanted as cuffs around large blood vessels; in essence, creating little hearts to help blood move through the arterial and venous system independent of the pumping ability of the main heart. Induced pluripotent stem cells could be used to develop these auxiliary pumps.