Title: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline
Date: May 29, 2020
Damage causing Alzheimer’s disease (AD) starts long before memories are lost. Our Doheny/UCLA collaborators used a special camera (OCT) in our cognitively healthy Brain Aging study participants to test if early damage could be seen in the eye. Optic nerve fiber size predicted who had early AD signs (our USC colleagues measured spinal fluid amyloid and tau) with 87% sensitivity, suggesting this might become a useful and simple screen for AD.