Colorectal Research

Colorectal Research

Colon and rectal surgery had traditionally been performed through large incisions with long postoperative hospital stays. Advances in minimally invasive surgery (laparoscopic and robotic) as well as evidence-based changes in perioperative management have made surgery less painful and allowed for earlier discharge from the hospital. We continue to reduce hospital length of stay and complications while reducing total direct hospital costs.

Colorectal cancer is the third most common malignancy among both men and women in the United States and represents the second leading cause of cancer death. In addition to known genetic syndromes that increase risk of cancer, there are a variety of risk factors in the general population for developing colorectal cancer. These risk factors include consumption of red meat and especially processed meats, obesity, and a sedentary lifestyle.

Clinical Outcomes Related to Colorectal and Pelvic Floor Surgery- enhanced Recovery after Surgery.

The molecular pathways that transform a benign colorectal polyp into cancer may include genetic mutations and epigenetic phenomena that turn genes on and off. The colorectal cancer research program at HMRI currently focuses on the role of increased body mass index on epigenetic changes that occur in the colon.

Anal Cancer: a Comparative Study of Patient Characteristics, Treatments and Outcomes.

While the incidence of colon and rectal cancer has been decreasing over the past several decades, the incidence of cancer of the anal canal has been increasing. We are using data from the National Cancer Database to study demographics, tumor characteristics, treatments received, and outcomes of patients with anal cancer, based on type of medical facility where diagnosis occurred. The impact on human health is that this study will allow patients, physicians, and cancer centers to understand the impact of multiple patient and tumor related factors on survival and patterns of recurrence for anal canal cancer.