Our Research Programs

Cardiovascular researchers focus on translational research, which is relevant to common cardiovascular disorders that cause mortality and morbidity in millions of people worldwide. Scientists study the pathophysiology of heart attack, heart failure, shock, and stroke and potential therapies.

Researchers in the Cardiovascular Signaling Laboratory delineate the multifactorial mechanisms that underlie signalling pathways associated with cardiac hypertrophy, heart failure, and ischemic brain injury. They investigate three core areas: The role of serine/threonine phosphatases (PHLPP) and AGC kinases in cardiovascular disease and aging, the effect of PHLPP isoforms on the mechanisms regulating neuroinflammation and aging in the brain, and signalling pathways altered with nicotine exposure.

Neuro- Cardio- Immunology Laboratory researchers investigate alterations targeting the adaptive and/or innate immune system to re-establish an adequately balanced immune response in neurological and cardiovascular diseases using the naturally occurring compound nicotinamide adenine dinucleotide (NAD+).