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Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite bio

Authors: C E Clay|||A M Namen|||G Atsumi|||A J Trimboli|||A N Fonteh|||K P High|||F H Chilton

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Publication Type: Journal Article

Date: 2001

DOI: 10.2310/6650.2001.33786

ID: 11523697

Affiliations:

Affiliations

    Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1042, USA.||||||||||||||||||

Abstract

The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has become a potential target for the prevention and treatment of breast cancer. However, recent in vitro and in vivo studies have raised the question of whether activation of PPARgamma leads to the promotion or reduction of tumor formation. Studies using several cancer cell lines, animal models, and a variety of PPARgamma agonists have shown discordant results, including changes in cellular proliferation, differentiation, and apoptosis of cancer cells and tumors.


Chemical List

    15-deoxy-delta(12,14)-prostaglandin J2|||Chromans|||Receptors, Cytoplasmic and Nuclear|||Thiazoles|||Thiazolidinediones|||Transcription Factors|||Troglitazone|||Prostaglandin D2