Cardiovascular Research

Phospholipase C activity increases in cerebrospinal fluid from migraineurs in proportion to the number of comorbid conditions: a

Authors: Alfred N Fonteh|||Janice M Pogoda|||Rainbow Chung|||Robert P Cowan|||Michael G Harrington

Affiliations: + Expand

Abstract

Migraineurs are more often afflicted by comorbid conditions than those without primary headache disorders, though the linking pathophysiological mechanism(s) is not known. We previously reported that phosphatidylcholine-specific phospholipase C (PC-PLC) activity in cerebrospinal fluid (CSF) increased during migraine compared to the same individual's well state. Here, we examined whether PC-PLC activity from a larger group of well-state migraineurs is related to the number of their migraine comorbidities.

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Chemical List

Type C Phospholipases|||phosphatidylcholine-specific phospholipase C

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Reference List

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