Amniotic fluid levels of phospholipase A2 in fetal rats with retinoic acid induced myelomeningocele: the potential "second hit"
Authors:R Agarwal|||M E Thornton|||A N Fonteh|||M G Harrington|||R H Chmait|||B H Grubbs
Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the
Publication Type: Journal Article
Date: 2016
DOI: 10.3109/14767058.2015.1112373
ID: 26513600
Affiliations:
Affiliations
a Keck School of Medicine of the University of Southern California , Los Angeles , CA , USA .|||b Division of Maternal-Fetal Medicine , Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center , Los Angeles , CA , USA , and.|||c Molecular Neurology Program, Huntington Medical Research Institutes , Pasadena , CA , USA.|||c Molecular Neurology Program, Huntington Medical Research Institutes , Pasadena , CA , USA.|||b Division of Maternal-Fetal Medicine , Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center , Los Angeles , CA , USA , and.|||b Division of Maternal-Fetal Medicine , Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center , Los Angeles , CA , USA , and.
Abstract
There is growing evidence of ongoing, in utero neurological damage in fetuses with myelomeningocele (MMC). Phospholipase A2 (PLA2) has known neurotoxic properties and is predominantly present in its secretory isoform (sPLA2) in meconium, the passage of which is increased in MMC fetuses. The objective of this study was to determine if amniotic fluid (AF) levels of PLA2 are elevated in a rat model of MMC.
