Potential role of renin-angiotensin system blockade for preventing myocardial ischemia/reperfusion injury and remodeling after m
Authors:
Journal: Postgraduate medicine
Publication Type: Journal Article
Date: 2011
DOI: 10.3810/pgm.2011.03.2263
ID: 21474893
Abstract
Experimental and clinical studies have demonstrated that myocardial ischemia induces activation of various components of the renin-angiotensin system (RAS), including angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensins, and angiotensin receptors, in the acute phase of myocardial infarction and the postinfarction remodeling process. Pharmacological inhibition of the RAS by administration of renin inhibitors, ACE inhibitors, and angiotensin receptor blockers has shown beneficial effects on the pathological processes of myocardial infarction in both experimental animal studies and clinical trials. However, the potential mechanisms responsible for the cardioprotection of RAS inhibition remain unclear. In this review, we discuss roles of RAS blocking in the prevention of myocardial ischemia/reperfusion injury and postinfarction remodeling.
Chemical List
- Angiotensin-Converting Enzyme Inhibitors|||Renin