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Cardioprotective Effects of Mitochondria-Targeted Peptide SBT-20 in two Different Models of Rat Ischemia/Reperfusion.

Authors: Wangde Dai|||Elissa Cheung|||Rick J Alleman|||Justin B Perry|||Mitchell E Allen|||David A Brown|||Robert A Kloner

Journal: Cardiovascular drugs and therapy

Publication Type: Journal Article

Date: 2016

DOI: NIHMS874132

ID: 27747447

Affiliations:

Affiliations

    HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA, 91105, USA. Wangdedai@yahoo.com.|||HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA, 91105, USA.|||Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.|||Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.|||Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.|||Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.|||HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA, 91105, USA.

Abstract

Dysfunctional mitochondria are considered to be the major source of intracellular reactive oxygen species and play a central role in the pathophysiology of myocardial ischemia/reperfusion. This study sought to determine effects of mitochondria-targeted cytoprotective peptide SBT-20 on myocardial infarct size in two different models of ischemia/reperfusion.

Chemical List

    Cardiotonic Agents|||Peptides|||Hydrogen Peroxide

Reference List

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