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The association of nadir CD4-T cell count and endothelial dysfunction in a healthy HIV cohort without major cardiovascular risk

Authors: Emad Mogadam|||Kevin King|||Kimberly Shriner|||Karen Chu|||Anders Sondergaard|||Kristal Young|||Morteza Naghavi|||Robert A Kloner

Journal: SAGE open medicine

Publication Type: Journal Article

Date: 2020

DOI: PMC7268551

ID: 32537154

Affiliations:

Affiliations

    Division of Cardiovascular Medicine, Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.|||Huntington Medical Research Institutes, Pasadena, CA, USA.|||Department of Medicine, Huntington Hospital, Pasadena, CA, USA.|||Huntington Medical Research Institutes, Pasadena, CA, USA.|||Huntington Medical Research Institutes, Pasadena, CA, USA.|||Division of Cardiology, Department of Medicine, Huntington Hospital, Pasadena, CA, USA.|||American Heart Technologies, Palo Alto, CA, USA.|||Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, CA, USA.

Abstract

HIV-infected population may have increased risk of cardiovascular disease. The prevalence of traditional cardiovascular disease risk factors such as hypertension, diabetes and dyslipidemia in HIV-infected individuals has made it difficult to assess the direct effects of HIV and immune factors on endothelial dysfunction and associated increased risk of atherosclerosis. The purpose of this study was to investigate indicators of endothelial dysfunction in an HIV cohort without hypertension and diabetes.


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