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Resting heart rate (variability) and cognition relationships reveal cognitively healthy individuals with pathological amyloid/ta

Authors: Cathleen Molloy|||Elizabeth H Choy|||Rebecca J Arechavala|||David Buennagel|||Anne Nolty|||Mitchell R Spezzaferri|||Caleb Sin|||Shant Rising|||Jeremy Yu|||Abdulhakim Al-Ezzi|||Michael T Kleinman|||Robert A Kloner|||Xianghong Arakaki

Journal: Frontiers in epidemiology

Publication Type: Journal Article

Date: 2023

DOI: NIHMS1919996

ID: 37587981

Affiliations:

Affiliations

    Cognition and Brain Integration Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.|||Department of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.|||Department of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.|||Clinical Neuroscience Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.|||Graduate School of Psychology & Marriage and Family Therapy, Fuller Theological Seminary, Pasadena, CA, United States.|||Graduate School of Psychology & Marriage and Family Therapy, Fuller Theological Seminary, Pasadena, CA, United States.|||Graduate School of Psychology & Marriage and Family Therapy, Fuller Theological Seminary, Pasadena, CA, United States.|||Graduate School of Psychology & Marriage and Family Therapy, Fuller Theological Seminary, Pasadena, CA, United States.|||Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, United States.|||Cognition and Brain Integration Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.|||Department of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.|||Clinical Neuroscience Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.|||Cognition and Brain Integration Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.

Abstract

Resting heart rate (HR) and heart rate variability (HRV) have been linked with cognition in the general population and in older individuals. The knowledge of this aspect of heart-brain relationship is relatively absent in older individuals with early Alzheimer's disease (AD) pathology. This study explores relationships of the HR, HRV, and cognition in cognitively healthy individuals with pathological amyloid/tau ratio (CH-PATs) in cerebral spinal fluid (CSF) compared to those with normal ratio (CH-NATs).

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