Effects of Intracoronary SuperSaturated Oxygen Therapy on Myocardial Blood Flow, Microvascular Obstruction, and Myocardial Salva
Authors:Pedro H C Melo|||Mateusz Kachel|||Kacper Nowak|||Yanping Cheng|||Paul Wilburn|||Donald Blum|||Ramu Perumal|||Jeffrey L Creech|||Gilles Barone-Rochette|||Robert A Kloner|||Juan F Granada|||Daniel Burkhoff|||Grzegorz L Kaluza
Journal: Journal of the American Heart Association
Publication Type: Journal Article
Date: 2025
DOI: 10.1161/JAHA.124.038891
ID: 40673580
Affiliations:
Affiliations
Skirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.|||Skirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.|||Skirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.|||Skirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.|||ZOLL TherOx, Inc. Irvine CA USA.|||ZOLL TherOx, Inc. Irvine CA USA.|||ZOLL TherOx, Inc. Irvine CA USA.|||ZOLL TherOx, Inc. Irvine CA USA.|||Department of Cardiology University Hospital Grenoble France.|||Division of Cardiovascular Medicine, Department of Medicine Keck School of Medicine of University of Southern California Los Angeles CA USA.|||Skirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.|||Skirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.|||Skirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.
Abstract
Early reperfusion after ST-segment-elevation myocardial infarction is essential for limiting infarct size. However, reperfusion injury can lead to progressive microvascular obstruction (MVO), reducing myocardial blood flow (MBF), aggravating ischemia and myocardial necrosis. We hypothesized that SuperSaturated Oxygen (SSO) Therapy may reduce infarct size by alleviating MVO, so we evaluated the effects of SSO on the time course of MBF and MVO in a preclinical ischemia/reperfusion model.
