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Left Ventricular Mass, Brain Magnetic Resonance Imaging, and Cognitive Performance: Results From the Strong Heart Study.

Authors: Bernhard Haring|||Adam Omidpanah|||Astrid M Suchy-Dicey|||Lyle G Best|||Steven P Verney|||Dean K Shibata|||Shelley A Cole|||Tauqeer Ali|||Barbara V Howard|||Dedra Buchwald|||Richard B Devereux

Journal: Hypertension (Dallas, Tex. : 1979)

Publication Type: Journal Article

Date: 2017

DOI: NIHMS900906

ID: 28893898

Affiliations:

Affiliations

    Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.). Haring_B@ukw.de.|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).|||Department of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).

Abstract

Left ventricular mass (LVM) has been shown to serve as a measure of target organ damage resulting from chronic exposure to several risk factors. Data on the association of midlife LVM with later cognitive performance are sparse. We studied 721 adults (mean age 56 years at baseline) enrolled in the Strong Heart Study (SHS, 1993-1995) and the ancillary CDCAI (Cerebrovascular Disease and Its Consequences in American Indians) Study (2010-2013), a study population with high prevalence of cardiovascular disease. LVM was assessed with transthoracic echocardiography at baseline in 1993 to 1995. Cranial magnetic resonance imaging and cognitive testing were undertaken between 2010 and 2013. Generalized estimating equations were used to model associations between LVM and later imaging and cognition outcomes. The mean follow-up period was 17 years. A difference of 25 g in higher LVM was associated with marginally lower hippocampal volume (0.01%; 95% confidence interval, 0.02-0.00; =0.001) and higher white matter grade (0.10; 95% confidence interval, 0.02-0.18; =0.014). Functionally, participants with higher LVM tended to have slightly lower scores on the modified mini-mental state examination (0.58; 95% confidence interval, 1.08-0.08; =0.024). The main results persisted after adjusting for blood pressure levels or vascular disease. The small overall effect sizes are partly explained by survival bias because of the high prevalence of cardiovascular disease in our population. Our findings emphasize the role of cardiovascular health in midlife as a target for the prevention of deleterious cognitive and functional outcomes in later life.

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