Cardiovascular Research

Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study.

Authors: Jordan P Lewis|||Astrid M Suchy-Dicey|||Carolyn Noonan|||Valarie Blue Bird Jernigan|||Jason G Umans|||Kimiko Domoto-Reilly|||Dedra S Buchwald|||Spero M Manson

Affiliations: + Expand

Abstract

American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.

---

Reference List

Akins S, Lanfear C, Cline S, & Mosher C (2013). Patterns and correlates of adult American Indian substance use. Journal of Drug Issues, 43(4), 497–516. 10.1177/0022042613491100|||Alfonso-Loeches S, Pascual M, & Guerri C (2013). Gender differences in alcohol-induced neurotoxicity and brain damage. Toxicology, 311(1–2), 27–34. 10.1016/j.tox.2013.03.001|||Beals J, Spicer P, Mitchell CM, Novins DK, Manson SM, Big Crow CK, Buchwald D, Chambers B, Christensen ML, Dillard DA, DuBray K, Espinoza PA, Fleming CM, Frederick AW, Gurley D, Jervis LL, Jim SM, Kaufman CE, Keane EM, Klein SA, … Yazzie LL (2003). Racial disparities in alcohol use: comparison of 2 American Indian reservation populations with national data. American Journal of Public Health, 93(10), 1683–1685. 10.2105/ajph.93.10.1683|||Centers for Disease Control & Prevention (CDC). (2012). Vital signs: Binge drinking prevalence, frequency, and intensity among adults - United States, 2010. MMWR Morbidity and Mortality Weekly Report, 61(1), 14–19. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6101a4.htm|||Dickerson DL, Fisher DG, Reynolds GL, Baig S, Napper LE, & Anglin MD (2012). Substance use patterns among high-risk American Indians/Alaska Natives in Los Angeles County. American Journal on Addictions, 21(5), 445–452. 10.1111/j.1521-0391.2012.00258.x|||Downer B, Jiang Y, Zanjani F, & Fardo D (2015). Effects of alcohol consumption on cognition and regional brain volumes among older adults. American Journal of Alzheimer’s Disease and Other Dementias, 30(4), 364–374. 10.1177/1533317514549411|||Gillespie CD, & Hurvitz KA (2013). Prevalence of hypertension and controlled hypertension - United States, 2007–2010. MMWR Suppl, 62(3), 144–148. https://www.cdc.gov/Mmwr/preview/mmwrhtml/su6203a24.htm|||Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, … Turner MB (2013). Executive summary: Heart disease and stroke statistics--2013 update: A report from the American Heart Association. Circulation, 127(1), 143–152. 10.1161/CIR.0b013e318282ab8f|||Gray RS, Fabsitz RR, Cowan LD, Lee ET, Welty TK, Jablonski KA, & Howard BV (2000). Relation of generalized and central obesity to cardiovascular risk factors and prevalent coronary heart disease in a sample of American Indians: The Strong Heart Study. International Journal of Obesity and Related Metabolic Disorders, 24(7), 849–860. 10.1038/sj.ijo.0801243|||Greene KM, Eitle TM, & Eitle D (2014). Adult social roles and alcohol use among American Indians. Addictive Behaviors, 39(9), 1357–1360. 10.1016/j.addbeh.2014.04.024|||Howard BV (1996a). Blood pressure in 13 American Indian communities: The Strong Heart Study. Public Health Reports, 111(Suppl 2), 47–48. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1381664/|||Howard BV (1996b). Risk factors for cardiovascular disease in individuals with diabetes. The Strong Heart Study. Acta Diabetologica, 33(3), 180–184. https://link.springer.com/article/10.1007/BF02048540|||Howard BV, Lee ET, Fabsitz RR, Robbins DC, Yeh JL, Cowan LD, & Welty TK (1996). Diabetes and coronary heart disease in American Indians: The Strong Heart Study. Diabetes, 45(Suppl 3), S6–13. 10.2337/diab.45.3.s6|||Howard BV, Lee ET, Yeh JL, Go O, Fabsitz RR, Devereux RB, & Welty TK (1996). Hypertension in adult American Indians. The Strong Heart Study. Hypertension, 28(2), 256–264. 10.1161/01.HYP.28.2.256|||Klatsky AL (2015). Alcohol and cardiovascular diseases: where do we stand today? Journal of Internal Medicine, 278(3), 238–250. 10.1111/joim.12390|||Knopman D, Boland LL, Mosley T, Howard G, Liao D, Szklo M, McGovern P, & Folsom AR (2001). Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology, 56(1), 42–48. 10.1212/wnl.56.1.42|||Lange EH, Nerland S, Jorgensen KN, Morch-Johnsen L, Nesvag R, Hartberg CB, Haukvik UK, Osnes K, Melle I, Andreassen OA, & Agartz I (2017). Alcohol use is associated with thinner cerebral cortex and larger ventricles in schizophrenia, bipolar disorder and healthy controls. Psychological Medicine, 47(4), 655–668. 10.1017/s0033291716002920|||Lee ET, Howard BV, Savage PJ, Cowan LD, Fabsitz RR, Oopik AJ, Yeh J, Go O, Robbins DC, & Welty TK (1995). Diabetes and impaired glucose tolerance in three American Indian populations aged 45–74 years. The Strong Heart Study. Diabetes Care, 18(5), 599–610. 10.2337/diacare.18.5.599|||Lee ET, Welty TK, Fabsitz R, Cowan LD, Le NA, Oopik AJ, Cucchiara AJ, Savage PJ, & Howard BV (1990). The Strong Heart Study. A study of cardiovascular disease in American Indians: Design and methods. American Journal of Epidemiology, 132(6), 1141–1155. 10.1093/oxfordjournals.aje.a115757|||Liput DJ, Pauly JR, Stinchcomb AL, & Nixon K (2017). Binge alcohol exposure transiently changes the endocannabinoid system: A potential target to prevent alcohol-induced neurodegeneration. Brain Sciences, 7(12), 1–18. 10.3390/brainsci7120158|||Marchant NL, Reed BR, DeCarli CS, Madison CM, Weiner MW, Chui HC, & Jagust WJ (2012). Cerebrovascular disease, beta-amyloid, and cognition in aging. Neurobiol Aging, 33(5), 1006.e25–e36. 10.1016/j.neurobiolaging.2011.10.001|||Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jimenez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, … Turner MB (2016). Executive summary: Heart disease and stroke statistics--2016 update: A report from the American Heart Association. Circulation, 133(4), 447–454. 10.1161/cir.0000000000000366|||Omran AJA, Saternos HC, Althobaiti YS, Wisner A, Sari Y, Nauli SM, & AbouAlaiwi WA (2017). Alcohol consumption impairs the ependymal cilia motility in the brain ventricles. Scientific Reports, 7(1), 13652. 10.1038/s41598-017-13947-3|||Ong KL, Cheung BM, Man YB, Lau CP, & Lam KS (2007). Prevalence, awareness, treatment, and control of hypertension among United States adults 1999–2004. Hypertension, 49(1), 69–75. 10.1161/01.hyp.0000252676.46043.18|||Ozsoy S, Durak AC, & Esel E (2013). Hippocampal volumes and cognitive functions in adult alcoholic patients with adolescent-onset. Alcohol, 47(1), 9–14. 10.1016/j.alcohol.2012.09.002|||Paul CA, Au R, Fredman L, Massaro JM, Seshadri S, Decarli C, & Wolf PA (2008). Association of alcohol consumption with brain volume in the Framingham study. Archives of Neurology, 65(10), 1363–1367. 10.1001/archneur.65.10.1363|||Piano MR (2017). Alcohol’s Effects on the Cardiovascular System. Alcohol Research, 38(2), 219–241. https://www.ncbi.nlm.nih.gov/pubmed/28988575|||Robin RW, Long JC, Rasmussen JK, Albaugh B, & Goldman D (1998). Relationship of binge drinking to alcohol dependence, other psychiatric disorders, and behavioral problems in an American Indian tribe. Alcoholism Clinical & Experimental Research, 22(2), 518–523. 10.1111/j.1530-0277.1998.tb03682.x|||Suchy-Dicey AM, Shibata D, Best LG, Verney SP, Longstreth WT Jr., Lee ET, Okin PM, Devereux R, O’Leary M, Ali T, Jensen PN, Muller C, Nelson LA, Rhoades E, Madhyastha T, Grabowski TJ, Beauchamp N, Umans JG, & Buchwald D (2016). Cranial magnetic resonance imaging in elderly American Indians: Design, methods, and implementation of the Cerebrovascular Disease and its Consequences in American Indians Study. Neuroepidemiology, 47(2), 67–75. 10.1159/000443277|||Suchy-Dicey AM, Shibata DK, Madhyastha TM, Grabowski TJ, Longstreth WT Jr., & Buchwald DS (2017). Findings of vascular brain injury and structural loss from cranial magnetic resonance imaging in elderly American Indians: The Strong Heart Study. Neuroepidemiology, 48(1–2), 39–47. 10.1159/000459624|||Sullivan EV, Deshmukh A, Desmond JE, Mathalon DH, Rosenbloom MJ, Lim KO, & Pfefferbaum A (2000). Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia. Archives of General Psychiatry, 57(9), 894–902. 10.1001/archpsyc.57.9.894|||Toutenburg H, & Rubin DB (1990). Multiple imputation for nonresponse in surveys. Statistical Papers, 31(1), 180–180.|||Wang GY, Demirakca T, van Eijk J, Frischknecht U, Ruf M, Ucar S, Hermann D, Mann K, Kiefer F, & Ende G (2016). Longitudinal mapping of gyral and sulcal patterns of cortical thickness and brain volume regain during early alcohol abstinence. European Addiction Research, 22(2), 80–89. 10.1159/000438456|||Wang W, Lee ET, Fabsitz RR, Devereux R, Best L, Welty TK, & Howard BV (2006). A longitudinal study of hypertension risk factors and their relation to cardiovascular disease: The Strong Heart Study. Hypertension, 47(3), 403–409. 10.1161/01.hyp.0000200710.29498.80|||Wang W, Zhang Y, Lee ET, Howard BV, Devereux RB, Cole SA, Best LG, Welty TK, Rhoades E, Yeh J, Ali T, Kizer JR, Kamel H, Shara N, Wiebers DO, & Stoner JA (2017). Risk factors and prediction of stroke in a population with high prevalence of diabetes: The Strong Heart Study. World Journal of Cardiovascular Diseases, 7(5), 145–162. 10.4236/wjcd.2017.75014|||Wardzala C, Murchison C, Loftis JM, Schenning KJ, Mattek N, Woltjer R, Kaye J, Quinn JF, & Wilhelm CJ (2018). Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians. Psychopharmacology (Berl), 235(3), 761–770. 10.1007/s00213-017-4791-6|||Welty TK, Lee ET, Yeh J, Cowan LD, Go O, Fabsitz RR, Le NA, Oopik AJ, Robbins DC, & Howard BV (1995). Cardiovascular disease risk factors among American Indians. The Strong Heart Study. American Journal of Epidemiology, 142(3), 269–287. 10.1093/oxfordjournals.aje.a117633|||Whitesell NR, Beals J, Crow CB, Mitchell CM, & Novins DK (2012). Epidemiology and etiology of substance use among American Indians and Alaska Natives: Risk, protection, and implications for prevention. American Journal of Drug and Alcohol Abuse, 38(5), 376–382. 10.3109/00952990.2012.694527|||Wilhelm CJ, Hashimoto JG, Roberts ML, Bloom SH, Beard DK, & Wiren KM (2015). Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling. Brain Research, 1601, 102–116. 10.1016/j.brainres.2015.01.002|||Yoon EJ, Choi JS, Kim H, Sohn BK, Jung HY, Lee JY, Kim DJ, Park SW, & Kim YK (2017). Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder. Scientific Reports, 7(1), 5744. 10.1038/s41598-017-06057-7|||Zhang Y, Galloway JM, Welty TK, Wiebers DO, Whisnant JP, Devereux RB, Kizer JR, Howard BV, Cowan LD, Yeh J, Howard WJ, Wang W, Best L, & Lee ET (2008). Incidence and risk factors for stroke in American Indians: The Strong Heart Study. Circulation, 118(15), 1577–1584. 10.1161/CIRCULATIONAHA.108.772285