Urinary selenium, cranial MRI, and cognitive function in American Indians: The Strong Heart Study.
Authors:
Journal: Environmental research
Publication Type: Journal Article
Date: 2025
DOI: NIHMS2051463
ID: 39842758
Abstract
Selenium (Se), a trace element found in soil and groundwater, is necessary for many biological functions, including cerebrovascular health, through selenoprotein formation. However, high concentrations may be harmful. American Indians face elevated cerebrovascular disease rates, which may be associated with other trace elements, such as Se. This cohort study evaluates associations of Se levels with brain health in older American Indians.
Chemical List
- Selenium
Reference List
- Genchi G, et al., Biological Activity of Selenium and Its Impact on Human Health. Int J Mol Sci, 2023. 24(3).|||Zhuo Z, et al., Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice. J Cereb Blood Flow Metab, 2023. 43(7): p. 1060–1076.|||Leiter O, et al., Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging. Cell Metab, 2022. 34(3): p. 408–423 e8.|||Ferdous KA, Knol LL, and Park HA, Association between selenium intake and cognitive function among older adults in the US: National Health and Nutrition Examination Surveys 2011–2014. J Nutr Sci, 2023. 12: p. e57.|||Harman D, Aging: a theory based on free radical and radiation chemistry. J Gerontol, 1956. 11(3): p. 298–300.|||Berr C, Arnaud J, and Akbaraly TN, Selenium and cognitive impairment: a brief-review based on results from the EVA study. Biofactors, 2012. 38(2): p. 139–44.|||Ma LY, et al., Association of thyroid disease with risks of dementia and cognitive impairment: A meta-analysis and systematic review. Front Aging Neurosci, 2023. 15: p. 1137584.|||Gao S, et al., Selenium level and cognitive function in rural elderly Chinese. Am J Epidemiol, 2007. 165(8): p. 955–65.|||Gerardo B, et al., Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort. Int J Environ Res Public Health, 2020. 17(17).|||Yan X, et al., A cross-sectional study of blood selenium concentration and cognitive function in elderly Americans: National Health and Nutrition Examination Survey 2011–2014. Ann Hum Biol, 2020. 47(7–8): p. 610–619.|||Kryscio RJ, et al., Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE). JAMA Neurol, 2017. 74(5): p. 567–573.|||Mendelsohn AB, et al., Use of antioxidant supplements and its association with cognitive function in a rural elderly cohort: the MoVIES Project. Monongahela Valley Independent Elders Survey. Am J Epidemiol, 1998. 148(1): p. 38–44.|||Basun H, et al., Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer’s disease. J Neural Transm Park Dis Dement Sect, 1991. 3(4): p. 231–58.|||Vinceti M, et al., A selenium species in cerebrospinal fluid predicts conversion to Alzheimer’s dementia in persons with mild cognitive impairment. Alzheimers Res Ther, 2017. 9(1): p. 100.|||Saito Y, Selenoprotein P as an in vivo redox regulator: disorders related to its deficiency and excess. J Clin Biochem Nutr, 2020. 66(1): p. 1–7.|||Vinceti M, et al., Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia. Sci Rep, 2023. 13(1): p. 8792.|||Vinceti M, et al., Selenium Species in Cerebrospinal Fluid and Hippocampal Volume among Individuals with Mild Cognitive Impairment. Environ Health Perspect, 2022. 130(11): p. 117701.|||Wang X, et al., Associations between plasma metal elements and risk of cognitive impairment among Chinese older adults. Front Aging Neurosci, 2024. 16: p. 1353286.|||Perri G, et al., The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and longitudinal analyses. Am J Clin Nutr, 2024. 120(5): p. 1019–1028.|||Koseoglu E, et al., Arsenic and selenium measurements in nail and hair show important relationships to Alzheimer’s disease in the elderly. J Trace Elem Med Biol, 2021. 64: p. 126684.|||Sanz Alaejos M and Diaz Romero C, Urinary selenium concentrations. Clin Chem, 1993. 39(10): p. 2040–52.|||Yoneyama S, et al., Dietary intake and urinary excretion of selenium in the Japanese adult population: the INTERMAP Study Japan. Eur J Clin Nutr, 2008. 62(10): p. 1187–93.|||Phiri FP, et al., Urine selenium concentration is a useful biomarker for assessing population level selenium status. Environ Int, 2020. 134: p. 105218.|||Longnecker MP, et al., Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake. Epidemiology, 1996. 7(4): p. 384–90.|||Lajin B, et al., Investigating the intra-individual variability in the human metabolic profile of urinary selenium. J Trace Elem Med Biol, 2016. 37: p. 31–36.|||Suchy-Dicey A, et al., Cognitive Correlates of MRI-defined Cerebral Vascular Injury and Atrophy in Elderly American Indians: The Strong Heart Study. J Int Neuropsychol Soc, 2020. 26(3): p. 263–275.|||Survey, U.S.G.
Geochemical and Mineralogical Maps, with Interpretation, for Soils of the Conterminous United States. Available from: https://pubs.usgs.gov/sir/2017/5118/sir20175118_element.php?el=34.|||Scheer J, et al., Arsenic species and selected metals in human urine: validation of HPLC/ICPMS and ICPMS procedures for a long-term population-based epidemiological study. Anal Methods, 2012. 4(2): p. 406–413.|||Suchy-Dicey A, et al., Comparing Vascular Brain Injury and Stroke by Cranial Magnetic Resonance Imaging, Physician-Adjudication, and Self-Report: Data from the Strong Heart Study. Neuroepidemiology, 2021. 55(5): p. 398–406.|||Shibata D, et al., Vascular Risk Factors and Findings on Brain MRI of Elderly Adult American Indians: The Strong Heart Study. Neuroepidemiology, 2019. 52(3–4): p. 173–180.|||Suchy-Dicey A, et al., Urinary Arsenic and Cadmium Associations with Findings from Cranial MRI in American Indians: Data from the Strong Heart Study. Environ Health Perspect, 2020. 128(12): p. 127009.|||Suchy-Dicey AM, et al., Epidemiology and prevalence of dementia and Alzheimer’s disease in American Indians: Data from the Strong Heart Study. Alzheimers Dement, 2024. 20(6): p. 4174–4184.|||Suchy-Dicey AM, et al., Findings of Vascular Brain Injury and Structural Loss from Cranial Magnetic Resonance Imaging in Elderly American Indians: The Strong Heart Study. Neuroepidemiology, 2017. 48(1–2): p. 39–47.|||Teng EL and Chui HC, The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry, 1987. 48(8): p. 314–8.|||Wechsler D, Wechsler Adult Intelligence Scale (4th ed.) (4th ed.).. 2008, San Antonio, TX:: Pearson..|||Benton AL, & Hansher K, Multilingual aphasia examination 197c, Iowa City, IO:: AJA Associates.|||Delis DC, Kramer JH, Kaplan E, & Ober BA, California Verbal Learning Test (CVLT-II) (2 ed.). US: The Psychological Corporation., (2000).|||Harrell FE, Regression modeling strategies: with applications to linear models, logistic regression, and survival analysis. Springer series in statistics. 2001, New York: Springer. xxii, 568 p.|||Zhang X, Zhong Y, and He K, The causal effects between selenium levels and the brain cortical structure: A two-sample Mendelian randomization study. Brain Behav, 2023. 13(12): p. e3296.|||Zhu Y, et al., Associations of cumulative depressive symptoms with subsequent cognitive decline and adverse health events: Two prospective cohort studies. J Affect Disord, 2023. 320: p. 91–97.|||Spiller HA, Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity. Clin Toxicol (Phila), 2018. 56(5): p. 313–326.|||Li Z, et al., Blood cadmium, lead, manganese, mercury, and selenium levels in American Indian populations: The Strong Heart Study. Environ Res, 2022. 215(Pt 3): p. 114101.|||Kim J, et al., Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies. Diabetes Metab J, 2019. 43(4): p. 447–460.