Stronger implicit interference in cognitively healthy older participants with higher risk of Alzheimer's disease.
Authors:
Journal: Alzheimer's & dementia (Amsterdam, Netherlands)
Publication Type: Journal Article
Date: 2022
DOI: PMC9489163
ID: 36187196
Abstract
Abnormal cerebrospinal fluid amyloid beta (Aβ) and tau levels have been revealed decades before symptoms onset in Alzheimer's disease (AD); however, the examination is usually invasive and inaccessible to most people. We thus aimed to develop a non-invasive behavioral test that targets early potential cognitive changes to gauge cognitive decline. Specifically, we hypothesized that older cognitive healthy participants would exhibit comparable performance when the task was explicit and relied on conscious cognition. However, when the task was implicit, the performance of participants at high and low risks for AD would bifurcate. That is, early changes in unconscious cognition could be linked to cognitive health.
Reference List
- Hebert LE, Weuve J, Scherr PA, Evans DA. Alzheimer disease in the United States (2010‐2050) estimated using the 2010 census. Neurology. 2013;80(19):1778‐1783. doi:10.1212/WNL.0b013e31828726f5|||Alzheimer's Association . 2019 Alzheimer's disease facts and figures. Alzheimers Dement. 2019;15(3):321‐387. doi:10.1016/j.jalz.2019.01.010|||Ganguli M, Rodriguez EG. Reporting of dementia on death certificates: a community study. J Am Geriatr Soc. 1999;47(7):842‐849. doi:10.1111/j.1532-5415.1999.tb03842.x|||Tom SE, Hubbard RA, Crane PK, et al. Characterization of dementia and Alzheimer's disease in an older population: updated incidence and life expectancy with and without dementia. Am J Public Health. 2015;105(2):408‐413. doi:10.2105/AJPH.2014.301935|||Larson EB, Shadlen MF, Wang L, et al. Survival after initial diagnosis of Alzheimer disease. Ann Intern Med. 2004;140(7):501. doi:10.7326/0003-4819-140-7-200404060-00008|||Rosenberg A, Ngandu T, Rusanen M, et al. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: the FINGER trial. Alzheimers Dement. 2018;14(3):263‐270. doi:10.1016/j.jalz.2017.09.006|||Mattsson‐Carlgren N, Leuzy A, Janelidze S, et al. The implications of different approaches to define AT(N) in Alzheimer disease. Neurology. 2020;94(21):e2233‐e2244. doi:10.1212/WNL.0000000000009485|||Folstein MF, Folstein SE, McHugh PR. “Mini‐mental state” a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189‐198. doi:10.1016/0022-3956(75)90026-6|||Saenz M, Buracas GT, Boynton GM. Global effects of feature‐based attention in human visual cortex. Nat Neurosci. 2002;5(7):631‐632. doi:10.1038/nn876|||Carrasco M, Ling S, Read S. Attention alters appearance. Nat Neurosci. 2004;7(3):308‐313. doi:10.1038/nn1194|||Kiefer M, Martens U. Attentional sensitization of unconscious cognition: task sets modulate subsequent masked semantic priming. J Exp Psychol Gen. 2010;139(3):464‐489. doi:10.1037/a0019561|||Hung SM, Wu DA, Shimojo S. Task‐induced attention load guides and gates unconscious semantic interference. Nat Commun. 2020;11(1):2088. doi:10.1038/s41467-020-15439-x|||Davidson DJ, Zacks RT, Williams CC. Stroop interference, practice, and aging. Aging Neuropsychol Cogn. 2003;10(2):85‐98. doi:10.1076/anec.10.2.85.14463|||Mutter SA, Naylor JC, Patterson ER. The effects of age and task context on Stroop task performance. Mem Cognit. 2005;33(3):514‐530. doi:10.3758/BF03193068|||Murray BD, Anderson MC, Kensinger EA. Older adults can suppress unwanted memories when given an appropriate strategy. Psychol Aging. 2015;30(1):9‐25. doi:10.1037/a0038611|||Lustig C, Hasher L, Zacks RT, Inhibitory deficit theory: recent developments in a “new view.” In: Gorfein DS, MacLeod CM, eds. Inhibition in Cognition. American Psychological Association; 2007:145‐162. 10.1037/11587-008|||Diamond A. Executive functions. Annu Rev Psychol. 2013;64(1):135‐168. doi:10.1146/annurev-psych-113011-143750|||Verhaeghen P, De Meersman L. Aging and the stroop effect: a meta‐analysis. Psychol Aging. 1998;13(1):120‐126. doi:10.1037/0882-7974.13.1.120|||Logan JM, Balota DA. Conscious and unconscious lexical retrieval blocking in younger and older adults. Psychol Aging. 2003;18(3):537‐550. doi:10.1037/0882-7974.18.3.537|||Dehaene S, Naccache L, Clec'H GL, et al. Imaging unconscious semantic priming. Science. 1998;395:597‐600. doi:10.1038/26967|||Dehaene S, Naccache L, Cohen L, et al. Cerebral mechanisms of word masking and unconscious repetition priming. Nat Neurosci. 2001;4(7):752‐758. doi:10.1038/89551|||Harrington MG, Chiang J, Pogoda JM, et al. Executive function changes before memory in preclinical alzheimer's pathology: a prospective, cross‐sectional, case control study. PLoS ONE. 2013;8(11):e79378. doi:10.1371/journal.pone.0079378|||Arakaki X, Lee R, King KS, Fonteh AN, Harrington MG. Alpha desynchronization during simple working memory unmasks pathological aging in cognitively healthy individuals. PLoS ONE. 2019;14(1):e0208517. doi:10.1371/journal.pone.0208517|||Castor KJ, Shenoi S, Edminster SP, et al. Urine dicarboxylic acids change in pre‐symptomatic Alzheimer's disease and reflect loss of energy capacity and hippocampal volume. PLoS ONE. 2020;15(4):e0231765. doi:10.1371/journal.pone.0231765|||Harrington MG, Edminster SP, Buennagel DP, et al. Four‐year longitudinal study of cognitively healthy individuals: csf amyloid/tau levels and nanoparticle membranes identify high risk for Alzheimer's disease. Alzheimers Dement. 2019;15(7):P299. doi:10.1016/j.jalz.2019.06.720|||Pan C, Korff A, Galasko D, et al. Diagnostic values of cerebrospinal fluid T‐Tau and Aβ42 using Meso Scale Discovery Assays for Alzheimer's disease. JAD. 2015;45(3):709‐719. doi:10.3233/JAD-143099|||Arakaki X, Hung SM, Rochart R, Fonteh AN, Harrington MG. Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau. Neurobiol Aging. 2022;112:87‐101. doi:10.1016/j.neurobiolaging.2021.11.009|||Bondi MW, Serody AB, Chan AS, et al. Cognitive and neuropathologic correlates of Stroop Color‐Word Test performance in Alzheimer's disease. Neuropsychology. 2002;16(3):335‐343. doi:10.1037/0894-4105.16.3.335|||Balota DA, Tse CS, Hutchison KA, Spieler DH, Duchek JM, Morris JC. Predicting conversion to dementia of the Alzheimer's type in a healthy control sample: the power of errors in Stroop color naming. Psychol Aging. 2010;25(1):208‐218. doi:10.1037/a0017474|||Bateman RJ, Xiong C, Benzinger TLS, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med. 2012;367(9):795‐804. doi:10.1056/NEJMoa1202753|||Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at‐risk elderly people (FINGER): a randomised controlled trial. The Lancet. 2015;385(9984):2255‐2263. doi:10.1016/S0140-6736(15)60461-5|||Stawski RS, Sliwinski MJ, Hofer SM. Between‐person and within‐person associations among processing speed, attention switching, and working memory in younger and older adults. Exp Aging Res. 2013;39(2):194‐214. doi:10.1080/0361073X.2013.761556|||Arechavala RJ, Rochart R, Kloner RA, et al. Task switching reveals abnormal brain‐heart electrophysiological signatures in cognitively healthy individuals with abnormal CSF amyloid/tau, a pilot study. Int J Psychophysiol. 2021;170:102‐111. doi:10.1016/j.ijpsycho.2021.10.007|||
United Nations. 2019. World population prospects 2019. https://population.un.org/wpp Published June 17, 2019. Accessed July 11, 2021. https://www.un.org/development/desa/publications/world‐population‐prospects‐2019‐highlights.html