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Obesity and its impact on transplantation and alloimmunity.

Authors: Timm Heinbokel|||Bernhard Floerchinger|||Andreas Schmiderer|||Karoline Edtinger|||Guangxiang Liu|||Abdallah Elkhal|||Stefan G Tullius

Journal: Transplantation

Publication Type: Journal Article

Date: 2013

DOI: 10.1097/TP.0b013e3182869d2f

ID: 23416683

Affiliations:

Affiliations

    Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.||||||||||||||||||

Abstract

Obesity has become an increasing problem in healthcare worldwide with far-reaching consequences. More obese patients with irreversible end-stage organ failure undergo organ transplantation, and organs from obese donors are more frequently used. A growing body of evidence suggests more frequent postoperative complications and inferior patient and graft survival linked to obesity. More recently, adipose tissue has been linked to chronic inflammatory processes potentially impacting alloimmune responses and graft quality.

Chemical List

    Isoantibodies