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Rapamycin Prolongs Graft Survival and Induces CD4+IFN-γ+IL-10+ Regulatory Type 1 Cells in Old Recipient Mice.

Authors: Markus Quante|||Timm Heinbokel|||Karoline Edtinger|||Koichiro Minami|||Hirofumi Uehara|||Yeqi Nian|||Haruhito Azuma|||Reza Abdi|||Abdallah Elkhal|||Stefan G Tullius

Journal: Transplantation

Publication Type: Journal Article

Date: 2018

DOI: NIHMS896276

ID: 28777210

Affiliations:

Affiliations

    Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.|||Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.|||Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.|||Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.|||Department of Urology, Osaka Medical College, Osaka, Japan.|||Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.|||Department of Surgery, University Hospital Regensburg, Regensburg, Germany.|||Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.|||Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.|||Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Abstract

Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood.


Chemical List

    Immunosuppressive Agents|||Interleukin-10|||Interferon-gamma|||Sirolimus

Reference List

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