Cardiovascular Research

Mast cells regulate CD4 T-cell differentiation in the absence of antigen presentation.

Authors: Hector Rodriguez Cetina Biefer|||Timm Heinbokel|||Hirofumi Uehara|||Virginia Camacho|||Koichiro Minami|||Yeqi Nian|||Suresh Koduru|||Rachid El Fatimy|||Ionita Ghiran|||Alexander J Trachtenberg|||Miguel A de la Fuente|||Haruhito Azuma|||Omid Akbari|||Stefan G Tullius|||Anju Vasudevan|||Abdallah Elkhal

Affiliations: + Expand

Abstract

Given their unique capacity for antigen uptake, processing, and presentation, antigen-presenting cells (APCs) are critical for initiating and regulating innate and adaptive immune responses. We have previously shown the role of nicotinamide adenine dinucleotide (NAD) in T-cell differentiation independently of the cytokine milieu, whereas the precise mechanisms remained unknown.

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Chemical List

NAD

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Reference List

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