New Princeton IV Proceedings Affirm Cardiovascular Safety of PDE5 Inhibitors

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PASADENA, Calif. — June 27, 2024 — A new publication co-authored by Dr. Robert A. Kloner, Chief Science Officer and Scientific Director of Cardiovascular Research at Huntington Medical Research Institutes (HMRI), presents the official proceedings of the Princeton IV Consensus Conference on Phosphodiesterase Type 5 (PDE5) Inhibitors and Cardiac Health, held at HMRI in March 2023.

Published in Sexual Medicine Reviews, the paper — “Proceedings of Princeton IV: PDE5 Inhibitors and Cardiac Health Symposium” — summarizes the conclusions of a multidisciplinary expert panel that reviewed emerging data on erectile dysfunction (ED), cardiovascular disease, and PDE5 inhibitor use.

The panel — including Raymond Rosen, Martin Miner, Arthur Burnett, Michael Blaha, Peter Ganz, Irwin Goldstein, Noel Kim, Tobias Kohler, Tom Lue, Kevin McVary, John Mulhall, Sharon Parish, Hossein Sadeghi-Nejad, Richard Sadovsky, Ira Sharlip, and Robert Kloner — issued several key clinical updates:

  • Erectile dysfunction is an early marker of cardiovascular risk, and men with ED should undergo comprehensive cardiovascular evaluation.

  • Coronary artery calcium (CAC) scoring is recommended for men with ED and intermediate cardiovascular risk.

  • PDE5 inhibitors remain safe for most men, including those treated for hypertension or lower urinary tract symptoms, though caution is warranted with concurrent nitrate or alpha-blocker use.

  • Retrospective studies suggest cardioprotective effects of long-term PDE5 inhibitor use, with consistently lower rates of adverse cardiac events in treated men.

  • The panel also addressed emerging indications for PDE5 inhibitors, their potential use in women, and concerns about supplement adulteration in over-the-counter products.

“These proceedings reinforce the remarkable safety record of PDE5 inhibitors and their potential role in protecting cardiovascular health,” said Dr. Kloner. “The Princeton IV meeting continued a decades-long collaboration between cardiology and sexual medicine — and we were honored to host it at HMRI.”

Full article: Sexual Medicine Reviews, June 2024