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Perifoveal Choriocapillaris Flow Deficits Associated With Cerebrospinal Fluid Aβ42/tau in Presymptomatic Alzheimer's Disease.

Authors: Jane W Chan|||Giulia Corradetti|||Xiaomeng Wu|||Natalie Astraea|||Xianghong Arakaki|||Alfred N Fonteh|||Astrid M Suchy-Dicey|||SriniVas Sadda

Journal: Translational vision science & technology

Publication Type: Journal Article

Date: 2025

DOI: PMC12126125

ID: 40434374

Affiliations:

Affiliations

    Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.|||Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.|||Analytical Biochemistry Core, Huntington Medical Research Institute, Pasadena, CA, USA.|||Analytical Biochemistry Core, Huntington Medical Research Institute, Pasadena, CA, USA.|||Cognition and Brain Integration Lab, Huntington Medical Research Institute, Pasadena, CA, USA.|||Biomarker and Neuro-Mechanism Lab, Huntington Medical Research Institute, Pasadena, CA, USA.|||Huntington Medical Research Institute, Pasadena, CA, USA.|||Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Abstract

This study investigated the association between swept-source OCTA (SS-OCTA) choriocapillaris flow deficit percentage (CC FD%) and cerebrospinal fluid (CSF) biomarkers in presymptomatic Alzheimer's disease (AD).


Chemical List

    Amyloid beta-Peptides|||tau Proteins|||amyloid beta-protein (1-42)|||Peptide Fragments|||Biomarkers

Reference List

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