Quick Links

Contact Us

Cellular mechanisms of infarct size reduction with ischemic preconditioning. Role of calcium?

Authors: K Przyklenk|||B Z Simkhovich|||B Bauer|||K Hata|||L Zhao|||G T Elliott|||R A Kloner

Journal: Annals of the New York Academy of Sciences

Publication Type: Journal Article

Date: 1999

DOI: 10.1111/j.1749-6632.1999.tb09236.x

ID: 10415532

Affiliations:

Affiliations

    Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017-2395, USA. Karinp@dnamail.com||||||||||||||||||

Abstract

Brief episodes of ischemia protect or "precondition" the heart and reduce infarct size caused by a subsequent sustained ischemic insult. Despite a decade of intensive investigation, the cellular mechanism(s) responsible for this paradoxical protection remain poorly understood. In this review, we focus on the emerging concept that alterations in intracellular calcium homeostasis may participate in either triggering and/or mediating infarct size reduction with preconditioning.

Chemical List

    Calcium