Cardiovascular Research

Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: an unlimited source of cells for myocard

Authors: Sharon Etzion|||Israel M Barbash|||Micha S Feinberg|||Parvin Zarin|||Liron Miller|||Esther Guetta|||Radka Holbova|||Robert A Kloner|||Laurence H Kedes|||Jonathan Leor

Affiliations: + Expand

Abstract

The muscle-specific MyoD family of transcription factors function as master genes that are able to prompt myogenesis in a variety of cells. The purpose of our study was to determine whether MyoD could induce primary cardiac fibroblasts, isolated from infarcted myocardium or pericardium, to undergo myogenic conversion in a clinically relevant approach.

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Chemical List

MyoD Protein