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Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study.

Authors: Boris Z Simkhovich|||Paul Marjoram|||Coralie Poizat|||Larry Kedes|||Robert A Kloner

Journal: Cardiovascular research

Publication Type: Journal Article

Date: 2003

DOI: 10.1016/s0008-6363(03)00399-7

ID: 12909328

Affiliations:

Affiliations

    Heart Institute, Good Samaritan Hospital, Los Angeles, CA 90017, USA.simkhovi@hsc.usc.edu||||||||||||

Abstract

Brief episodes of ischemia of 20 min or less have the potential to protect the heart. Such episodes are associated primarily with reversible ischemic injury yet they induce changes in gene expression. The purpose of the study was to determine whether activation of protective genes takes place within 4 h following a brief episode of ischemia that would mimic angina pectoris.

Chemical List

    Calgranulin A|||Calgranulin B|||HSP27 Heat-Shock Proteins|||HSP70 Heat-Shock Proteins|||Heat-Shock Proteins|||Hspb1 protein, rat|||Neoplasm Proteins|||Plasminogen Activator Inhibitor 1