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Time course of the interaction between tadalafil and nitrates.

Authors: Robert A Kloner|||Adolph M Hutter|||Jeffrey T Emmick|||Malcolm I Mitchell|||Jonathan Denne|||Graham Jackson

Journal: Journal of the American College of Cardiology

Publication Type: Clinical Trial

Date: 2003

DOI: 10.1016/j.jacc.2003.09.023

ID: 14642699

Affiliations:

Affiliations

    The Heart Institute, Good Samaritan Hospital, Cardiovascular Division, Keck School of Medicine, University of Southern California, Los Angeles, California 90017, USA. rkloner@goodsam.org|||||||||||||||

Abstract

This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h.

Chemical List

    Carbolines|||Nitrates|||Phosphodiesterase Inhibitors|||Tadalafil