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Effects of acetaminophen on myocardial infarct size in rats.

Authors: Wangde Dai|||Robert A Kloner

Journal: Journal of cardiovascular pharmacology and therapeutics

Publication Type: Comparative Study

Date: 2003

DOI: 10.1177/107424840300800405

ID: 14740077

Affiliations:

Affiliations

    The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, Calif 90017, USA.|||

Abstract

Acetaminophen is widely prescribed as an analgesic agent in hospitals and clinics. However, acetaminophen theoretically could influence myocardial infarct size by reducing prostaglandin synthesis in vivo. To date, the effect of acetaminophen on myocardial infarct size is unknown. The present study investigated (1) whether acetaminophen has any effect on myocardial infarct size when given in an analgesic dose and (2) whether acetaminophen can affect the cardioprotective effect of the early phase of ischemic preconditioning in rats.

Chemical List

    Analgesics, Non-Narcotic|||Acetaminophen