Cardiovascular Research

Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normo

Authors: Robert A Kloner|||Graham Jackson|||Jeffrey T Emmick|||Malcolm I Mitchell|||Alun Bedding|||Margaret R Warner|||Alvaro Pereira

Affiliations: + Expand

Abstract

Tadalafil, a phosphodiesterase type 5 inhibitor, is effective therapy for erectile dysfunction (ED). Men with ED have a high incidence of comorbid conditions including cardiovascular disease, diabetes mellitus and benign prostatic hyperplasia. Although phosphodiesterase type 5 inhibitors are safe when administered with most medications, sildenafil given with doxazosin and vardenafil given with terazosin evoke orthostatic hypotension in some patients. We examined the hemodynamic interactions of tadalafil with the alpha-blockers doxazosin and tamsulosin.

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Chemical List

Adrenergic alpha-Antagonists|||Carbolines|||Sulfonamides|||Tadalafil|||Phosphoric Diester Hydrolases|||3',5'-Cyclic-GMP Phosphodiesterases|||Cyclic Nucleotide Phosphodiesterases, Type 5|||PDE5A protein, human|||Tamsulosin|||Doxazosin