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Washout of transplanted cells from the heart: a potential new hurdle for cell transplantation therapy.

Authors: Joan Dow|||Boris Z Simkhovich|||Larry Kedes|||Robert A Kloner

Journal: Cardiovascular research

Publication Type: Journal Article

Date: 2005

DOI: 10.1016/j.cardiores.2005.04.011

ID: 15907822

Affiliations:

Affiliations

    Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, Los Angeles, CA 90017, USA.|||||||||

Abstract

The number of viable transplanted cells in the heart is sharply decreased shortly after cell injection. The exact mechanics of cell loss are unclear. We hypothesized that immature cardiac cells transplanted directly into rat heart could be washed out via the cardiac vasculature, and carried to other organs.

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