Cardiovascular Research

Preconditioning does not attenuate myocardial stunning.

Authors: M Ovize|||K Przyklenk|||S L Hale|||R A Kloner

Affiliations: + Expand

Abstract

Despite numerous reports that one or more episodes of brief coronary artery occlusion preconditions the myocardium and dramatically reduces myocardial infarct size produced by a subsequent prolonged ischemia, we recently demonstrated that preconditioning does not attenuate contractile dysfunction in the peri-infarct tissue. However, the specific effects of preconditioning on myocardium in which wall motion has not been compromised by the preconditioning regimen per se and is further submitted to a short ischemic insult (that is, not confounded by necrosis) remain unknown.

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Chemical List

Phosphocreatine|||Adenosine Triphosphate