Cardiovascular Research

Acetaminophen and myocardial stunning after transient ischemia in rabbit hearts.

Authors: Sharon L Hale|||Robert A Kloner

Affiliations: + Expand

Abstract

Myocardial stunning is a lingering contractile dysfunction that occurs after brief ischemia, even in the absence of necrosis. Recent studies have shown that acetaminophen may have some benefit on the return of left ventricular function after brief global ischemia in an in vitro model. This study was conducted to determine whether treatment with acetaminophen results in enhanced myocardial tolerance to transient ischemia-reperfusion by improving left ventricular function and decreasing stunning in an in vivo model.

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Chemical List

Analgesics, Non-Narcotic|||Cardiotonic Agents|||Acetaminophen