Cardiovascular Research

Postconditioning markedly attenuates ventricular arrhythmias after ischemia-reperfusion.

Authors: Robert A Kloner|||Joan Dow|||Anil Bhandari

Affiliations: + Expand

Abstract

Brief periods of reocclusion (postconditioning) during early reperfusion reduce myocardial infarct size. Whether postconditioning has an effect on lethal ventricular arrhythmias independent of infarction in an in-vivo regional ischemia model is unknown. The purpose of this study was to determine if postconditioning limited reperfusion arrhythmias in a necrosis-free model.