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Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts.

Authors: Hyosook Hwang|||Joseph M Arcidi|||Sharon L Hale|||Boris Z Simkhovich|||Luiz Belardinelli|||Arvinder K Dhalla|||John C Shryock|||Robert A Kloner

Journal: Circulation

Publication Type: Journal Article

Date: 2009

DOI: 10.1161/CIRCULATIONAHA.108.844167

ID: 19752362

Affiliations:

Affiliations

    The Heart Institute, Good Samaritan Hospital, Los Angles, CA 90017, USA.|||||||||||||||||||||

Abstract

Ranolazine (Ran), an antianginal agent, inhibits late Na(+) current. The purpose of this study was to determine whether there was an added benefit of adding Ran to cardioplegia (CP) in a model of global ischemia/reperfusion.

Chemical List

    Acetanilides|||Piperazines|||Tetrodotoxin|||Sodium|||Ranolazine