Cardiovascular Research

The antianginal agent ranolazine is a potent antiarrhythmic agent that reduces ventricular arrhythmias: through a mechanism favo

Authors: Robert A Kloner|||Joan S Dow|||Anil Bhandari

Affiliations: + Expand

Abstract

The antianginal agent ranolazine (R) has shown some promise as an antiarrhythmic agent but its mechanism of action is not known. Previously, we have shown that R suppresses ventricular arrhythmias at a concentration >10 μM that may affect multiple ion currents including IKr.

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Chemical List

Acetanilides|||Anti-Arrhythmia Agents|||Piperazines|||Sodium Channel Blockers|||Ranolazine