Cardiovascular Research

An apoptosis signal-regulating kinase 1 inhibitor reduces cardiomyocyte apoptosis and infarct size in a rat ischemia-reperfusion

Authors: Paul Z Gerczuk|||David G Breckenridge|||John T Liles|||Grant R Budas|||John C Shryock|||Luiz Belardinelli|||Robert A Kloner|||Wangde Dai

Affiliations: + Expand

Abstract

We determined whether a small molecule inhibitor of apoptosis signal-regulating kinase 1 (ASK1-i) could reduce myocardial infarct size in a rat ischemia/reperfusion model.

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Chemical List

Protein Kinase Inhibitors|||MAP Kinase Kinase Kinase 5