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Intramyocardial injection of heart tissue-derived extracellular matrix improves postinfarction cardiac function in rats.

Authors: Wangde Dai|||Paul Gerczuk|||Yuanyuan Zhang|||Leona Smith|||Oleg Kopyov|||Gregory L Kay|||Aarne J Jyrala|||Robert A Kloner

Journal: Journal of cardiovascular pharmacology and therapeutics

Publication Type: Journal Article

Date: 2013

DOI: 10.1177/1074248412472257

ID: 23345062

Affiliations:

Affiliations

    The Heart Institute of Good Samaritan Hospital and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA 90017, USA. wangdedai@yahoo.com|||||||||||||||||||||

Abstract

We determined whether implantation of heart tissue-derived decellularized matrix, which contains native biochemical and structural matrix composition, could thicken the infarcted left ventricular (LV) wall and improve LV function in a rat myocardial infarction model.

Chemical List

    Angiogenesis Inducing Agents|||Biomarkers|||Cardiotonic Agents|||Tissue Extracts|||Proto-Oncogene Proteins c-kit