Combined remote perconditioning and postconditioning failed to attenuate infarct size and contractile dysfunction in a rat model
Authors:Jaspreet Sachdeva|||Wangde Dai|||Paul Z Gerczuk|||Robert A Kloner
Journal: Journal of cardiovascular pharmacology and therapeutics
Publication Type: Journal Article
Date: 2014
DOI: 10.1177/1074248413518967
ID: 24607766
Affiliations:
Affiliations
The Heart Institute of Good Samaritan Hospital, and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.|||The Heart Institute of Good Samaritan Hospital, and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.|||The Heart Institute of Good Samaritan Hospital, and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.|||The Heart Institute of Good Samaritan Hospital, and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA, USA rkloner@goodsam.org.
Abstract
Although preconditioning remains one of the most powerful maneuvers to reduce myocardial infarct size, it is not feasible in the clinical setting to pretreat patients prior to acute myocardial infarction (MI). The purpose of this study was to investigate the effect of more clinically relevant therapies of remote perconditioning, postconditioning, and the combined effect of remote perconditioning and postconditioning on myocardial infarct size in an anesthetized rat model.
