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Capsaicin-induced cardioprotection. Is hypothermia or the salvage kinase pathway involved?

Authors: Joan Dow|||Boris Z Simkhovich|||Sharon L Hale|||Gregory Kay|||Robert A Kloner

Journal: Cardiovascular drugs and therapy

Publication Type: Journal Article

Date: 2014

DOI: 10.1007/s10557-014-6527-8

ID: 24839185

Affiliations:

Affiliations

    Good Samaritan Hospital, Heart Institute, 1225 Wilshire Boulevard, Los Angeles, CA, 90017, USA.||||||||||||

Abstract

Topical capsaicin application was shown to reduce infarct size in experimental animal models. We hypothesized that cardioprotective properties of topical capsaicin application could be related to its hypothermic effect.

Chemical List

    Cardiotonic Agents|||Proto-Oncogene Proteins c-akt|||Mitogen-Activated Protein Kinase 1|||Mitogen-Activated Protein Kinase 3|||Capsaicin