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Rapid Induction of Hypothermia by the ThermoSuit System Profoundly Reduces Infarct Size and Anatomic Zone of No Reflow Following

Authors: Michael J Herring|||Wangde Dai|||Sharon L Hale|||Robert A Kloner

Journal: Journal of cardiovascular pharmacology and therapeutics

Publication Type: Journal Article

Date: 2015

DOI: 10.1177/1074248414535664

ID: 24906542

Affiliations:

Affiliations

    Heart Institute, Good Samaritan Hospital, Los Angeles, CA, USA mherring26@gmail.com.|||Heart Institute, Good Samaritan Hospital, Los Angeles, CA, USA Department of Cardiology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.|||Heart Institute, Good Samaritan Hospital, Los Angeles, CA, USA.|||Heart Institute, Good Samaritan Hospital, Los Angeles, CA, USA Department of Cardiology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA kloner@hmri.org.

Abstract

Although hypothermia reduces myocardial infarct size, noninvasive and rapid cooling methods are lacking. This study tests the effectiveness of a novel cooling apparatus on myocardial infarct size and no-reflow area in 2 models of coronary artery occlusion (CAO).