Cardiovascular Research

Rapid Surface Cooling by ThermoSuit System Dramatically Reduces Scar Size, Prevents Post-Infarction Adverse Left Ventricular Rem

Authors: Wangde Dai|||Michael J Herring|||Sharon L Hale|||Robert A Kloner

Affiliations: + Expand

Abstract

The long-term effects of transient hypothermia by the non-invasive ThermoSuit apparatus on myocardial infarct (MI) scar size, left ventricular (LV) remodeling, and LV function were assessed in rat MI model.

---

Reference List

Herring MJ, Dai W, Hale SL, Kloner RA. Rapid induction of hypothermia by the ThermoSuit system profoundly reduces infarct size and anatomic zone of no reflow following ischemia-reperfusion in rabbit and rat hearts. J Cardiovasc Pharmacol Ther. 2015;20:193–202.|||Howes D, Ohley W, Dorian P, Klock C, Freedman R, Schock R, Krizanac D, Holzer M. Rapid induction of therapeutic hypothermia using convective-immersion surface cooling: safety, efficacy and outcomes. Resuscitation. 2010;8:388–392.|||Hoedemaekers CW, Ezzahti M, Gerritsen A, van der Hoeven JG. Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study. Crit Care. 2007;11:R91.|||Hamamoto H, Sakamoto H, Leshnower BG, Parish LM, Kanemoto S, Hinmon R, Plappert T, Miyamoto S, St John-Sutton MG, Gorman JH, III, Gorman RC. Very mild hypothermia during ischemia and reperfusion improves postinfarction ventricular remodeling. Ann Thorac Surg. 2009;87:172–177.|||Kanemoto S, Matsubara M, Noma M, Leshnower BG, Parish LM, Jackson BM, Hinmon R, Hamamoto H, Gorman JH, III, Gorman RC. Mild hypothermia to limit myocardial ischemia-reperfusion injury: importance of timing. Ann Thorac Surg. 2009;87:157–163.|||Hale SL, Dave RH, Kloner RA. Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia. Basic Res Cardiol. 1997;92:351–357.|||Simkhovich BZ, Hale SL, Kloner RA. Metabolic mechanism by which mild regional hypothermia preserves ischemic tissue. J Cardiovasc Pharmacol Ther. 2004;9:83–90.|||Ning XH, Xu CS, Song YC, Xiao Y, Hu YJ, Lupinetti FM, Portman MA. Hypothermia preserves function and signaling for mitochondrial biogenesis during subsequent ischemia. Am J Physiol. 1998;274:H786–H793.|||Yang X, Liu Y, Yang XM, Hu F, Cui L, Swingle MR, Honkanen RE, Soltani P, Tissier R, Cohen MV, Downey JM. Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity. Basic Res Cardiol. 2011;106:421–430.|||Hale SL, Dae MW, Kloner RA. Hypothermia during reperfusion limits ‘no-reflow’ injury in a rabbit model of acute myocardial infarction. Cardiovasc Res. 2003;59:715–722.|||Hamamoto H, Leshnower BG, Parish LM, Sakamoto H, Kanemoto S, Hinmon R, Miyamoto S, Gorman JH, III, Gorman RC. Regional heterogeneity of myocardial reperfusion injury: effect of mild hypothermia. Ann Thorac Surg. 2009;87:164–171.|||Qing M, Vazquez-Jimenez JF, Schumacher K, Bhardwaj RS, Klosterhalfen B, Minkenberg R, Messmer BJ, von Bernuth G, Seghaye MC. Moderate hypothermia during cardiopulmonary bypass increases intramyocardial synthesis of heat shock protein 72. J Thorac Cardiovasc Surg. 2002;124:724–731.|||Ning XH, Chen SH, Xu CS, Li L, Yao LY, Qian K, Krueger JJ, Hyyti OM, Portman MA. Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis. J Appl Physiol. 2002;92:2200–2207.|||Anttila V, Hagino I, Zurakowski D, Lidov HG, Jonas RA. Higher bypass temperature correlates with increased white cell activation in the cerebral microcirculation. J Thorac Cardiovasc Surg. 2004;127:1781–1788.|||Chello M, Mastroroberto P, Romano R, Ascione R, Pantaleo D, De Amicis V. Complement and neutrophil activation during cardiopulmonary bypass: a randomized comparison of hypothermic and normothermic circulation. Eur J Cardiothorac Surg. 1997;11:162–168.|||Herring MJ, Hale SL, Dai W, Oskui PM, Kloner RA. Hypothermia in the setting of experimental acute myocardial infarction: a comprehensive review. Ther Hypothermia Temp Manag. 2014;4:159–167.|||Ly HQ, Denault A, Dupuis J, Vadeboncoeur A, Harel F, Arsenault A, Gibson CM, Bonan R. A pilot study: the noninvasive surface cooling thermoregulatory system for mild hypothermia induction in acute myocardial infarction (the NICAMI study) Am Heart J. 2005;150:933.e9–933.e13.|||Freedman R, Cote M, Schock R, Schofield L, Ohley W. Rapid non-invasive whole body cooling via a skin contacting circulating thin layer of cold water. Circulation. 2003;108:419–420.|||Lewis T. The nocisensor system of nerves and its reactions. BMJ. 1937;1:491–494.|||Daanen HA, Van de Linde FJ, Romet TT, Ducharme MB. The effect of body temperature on the hunting response of the middle finger skin temperature. Eur J Appl Physiol Occup Physiol. 1997;76:538–543.|||Mokhtarani M, Mahgoub AN, Morioka N, Doufas AG, Dae M, Shaughnessy TE, Sessler DI. Buspirone and meperidine synergistically reduce the shivering threshold. Anesth Analg. 2001;93:1233–1239.|||Nichol G, Strickland W, Shavelle D, Maehara A, Ben-Yehuda O, Genereux P, Dressler O, Parvataneni R, Nichols M, McPherson J, Barbeau G, Laddu A, Elrod JA, Tully GW, Ivanhoe R, Stone GW VELOCITY Investigators. Prospective, multicenter, randomized, controlled pilot trial of peritoneal hypothermia in patients with ST-segment- elevation myocardial infarction. Circ Cardiovasc Interv. 2015;8:e001965.