Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac functi
Authors:Jianru Shi|||Wangde Dai|||Juan Carreno|||Sharon L Hale|||Robert A Kloner|||Gregory L Kay
Journal: Life sciences
Publication Type: Journal Article
Date: 2019
DOI: 10.1016/j.lfs.2019.04.026
ID: 30991060
Affiliations:
Affiliations
HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America; Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA 90017-2395, United States of America. Electronic address: jianru.shi@hmri.org.|||HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America; Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA 90017-2395, United States of America.|||HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America.|||HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America.|||HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America; Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA 90017-2395, United States of America.|||HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America.
Abstract
The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model.
