5-Fluorouracil cardiotoxicity: left ventricular dysfunction and effect of coronary vasodilators.
Authors:
Journal: The American journal of the medical sciences
Publication Type: Case Reports
Date: 1987
DOI: 10.1097/00000441-198710000-00004
ID: 3661619
Abstract
Seven patients developed clinical features simulating myocardial ischemia less than 72 hours after 12 of 13 separate intravenous 5-fluorouracil administrations; 9 episodes were associated with chest pain, 3 with hypotension, 3 with ventricular tachycardia and 1 with cardiogenic shock. Left ventricular dysfunction was demonstrated by echocardiography in 5 separate episodes, 2 with interval improvement upon repeat echocardiograms. Pretreatment with nitrates and/or calcium channel blockers failed to prevent recurrence of cardiotoxicity during 5 of 6 repeat 5-fluorouracil administrations. Therapy with 5-fluorouracil is associated with cardiotoxicity simulating myocardial ischemia with left ventricular dysfunction. Pretreatment with coronary vasodilators may not prevent this phenomenon.
Chemical List
- Vasodilator Agents|||Fluorouracil