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Inflammatory response to chronic nicotine-containing electronic cigarette exposure in a rat model of myocardial infarction.

Authors: Jianru Shi|||Wangde Dai|||Juan Carreno|||Jaspreet Sachdeva|||Jesus Chavez|||Michael T Kleinman|||David A Herman|||Rebecca J Arechavala|||Irene Hasen|||Amanda Ting|||Robert A Kloner

Journal: Tobacco induced diseases

Publication Type: Journal Article

Date: 2025

DOI: PMC12125711

ID: 40453633

Affiliations:

Affiliations

    Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, United States.|||Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, United States.|||Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, United States.|||Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, United States.|||Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, United States.|||Department of Environmental and Occupational Health, University of California Irvine, Irvine, United States.|||Department of Environmental and Occupational Health, University of California Irvine, Irvine, United States.|||Department of Environmental and Occupational Health, University of California Irvine, Irvine, United States.|||Department of Environmental and Occupational Health, University of California Irvine, Irvine, United States.|||Department of Environmental and Occupational Health, University of California Irvine, Irvine, United States.|||Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, United States.

Abstract

The long-term effects of chronic electronic cigarette (e-cigarette) exposure on lung and heart inflammation during the healing phase of myocardial infarction (MI) remain unexplored. Additionally, the impact of e-cigarette exposure on blood parameters in this context is unclear. This study aims to assess e-cigarette with nicotine (e-cig Nic+) effects on lung histology, inflammatory gene expression in cardiac tissue, and blood parameters during MI recovery.


Reference List

    Birdsey J, Cornelius M, Jamal A, et al. . Tobacco product use among U.S. middle and high school students - National Youth Tobacco Survey, 2023. MMWR Morb Mortal Wkly Rep. 2023;72(44):1173-1182. doi:10.15585/mmwr.mm7244a1|||Zong H, Hu Z, Li W, et al. . Electronic cigarettes and cardiovascular disease: epidemiological and biological links. Pflugers Arch. 2024;476(6):875-888. doi:10.1007/s00424-024-02925-0|||Traboulsi H, Cherian M, Abou Rjeili M, et al. . Inhalation toxicology of vaping products and implications for pulmonary health. Int J Mol Sci. 2020;21(10):3495. doi:10.3390/ijms21103495|||Goriounova NA, Mansvelder HD. Short- and long-term consequences of nicotine exposure during adolescence for prefrontal cortex neuronal network function. Cold Spring Harb Perspect Med. 2012;2(12):a012120. doi:10.1101/cshperspect.a012120|||Biery DW, Berman AN, Singh A, et al. . Association of smoking cessation and survival among young adults with myocardial infarction in the partners YOUNG-MI Registry. JAMA Netw Open. 2020;3(7):e209649. doi:10.1001/jamanetworkopen.2020.9649|||Dai W, Shi J, Siddarth P, et al. . Effects of electronic cigarette vaping on cardiac and vascular function, and post-myocardial infarction remodeling in rats. Cardiovasc Toxicol. 2024;24(2):199-208. doi:10.1007/s12012-024-09835-8|||Scott A, Lugg ST, Aldridge K, et al. . Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages. Thorax. 2018;73:1161-1169. doi:10.1136/thoraxjnl-2018-211663|||Shields PG, Berman M, Brasky TM, et al. . A review of pulmonary toxicity of electronic cigarettes in the context of smoking: a focus on inflammation. Cancer Epidemiol Biomarkers Prev. 2017;26(8):1175-1191. doi:10.1158/1055-9965.EPI-17-0358|||Masso-Silva JA, Byun MK, Alexander LEC. Acute and chronic effects of vaping electronic devices on lung physiology and inflammation. Curr Opin Physiol. 2021;22:100447. doi:10.1016/j.cophys.2021.06.001|||Garcia-Arcos I, Geraghty P, Baumlin N, et al. . Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner. Thorax. 2016;71(12):1119-1129. doi:10.1136/thoraxjnl-2015-208039|||Schweitzer KS, Chen SX, Law S, et al. . Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L175-L187. doi:10.1152/ajplung.00411.2014|||Suryadinata RV, Wirjatmadi B, Adriani M, Sumarni S. The effects of exposure duration to electronic cigarette smoke on differences in superoxide dismutase and malondialdehyde in blood of Wistar rats. Int J Curr Pharm Res. 2019;11(3):13-16. doi:10.22159/ijcpr.2019v11i3.34084|||Snoderly HT, Alkhadrawi H, Panchal DM, et al. . Short-term exposure of female BALB/cJ mice to e-cigarette aerosol promotes neutrophil recruitment and enhances neutrophil-platelet aggregation in pulmonary microvasculature. J Toxicol Environ Health A. 2023;86(8):246-262. doi:10.1080/15287394.2023.2184738|||Corriden R, Moshensky A, Bojanowski CM, et al. . E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation. Am J Physiol Cell Physiol. 2020;318(1):C205-C214. doi:10.1152/ajpcell.00045.2019|||Piao WH, Campagnolo D, Dayao C, Lukas RJ, Wu J, Shi FD. Nicotine and inflammatory neurological disorders. Acta Pharmacol Sin. 2009;30(6):715-722. doi:10.1038/aps.2009.67|||Cool T, Baena ARY, Forsberg EC. Clearing the haze: how does nicotine affect hematopoiesis before and after birth? Cancers (Basel). 2021;14(1):184. doi:10.3390/cancers14010184|||Espinoza-Derout J, Hasan KM, Shao XM, et al. . Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice. Am J Physiol Heart Circ Physiol. 2019;317(2):H445-H459. doi:10.1152/ajpheart.00738.2018|||Prabhu SD, Frangogiannis NG. The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circ Res. 2016;119(1):91-112. doi:10.1161/CIRCRESAHA.116.303577|||Hom S, Chen L, Wang T, Ghebrehiwet B, Yin W, Rubenstein DA. Platelet activation, adhesion, inflammation, and aggregation potential are altered in the presence of electronic cigarette extracts of variable nicotine concentrations. Platelets. 2016;27(7):694-702. doi:10.3109/09537104.2016.1158403|||Qasim H, Karim ZA, Silva-Espinoza JC, et al. . Short-term e-cigarette exposure increases the risk of thrombogenesis and enhances platelet function in mice. J Am Heart Assoc. 2018;7(15):e009264. doi:10.1161/JAHA.118.009264