AI-CVD-AF: A Novel Atrial Fibrillation Prediction Model Based on Coronary Artery Calcium Scans.
Authors:Seyed Reza Mirjalili|||Kyle Atlas|||Anthony P Reeves|||Chenyu Zhang|||Jakob Wasserthal|||Amir Azimi|||Ali Hashemi|||Mohammadhossein Mozafarybazargany|||Thomas Atlas|||Claudia I Henschke|||David F Yankelevitz|||Javier J Zulueta|||Wenjun Fan|||Jeffrey I Mechanick|||Andrea D Branch|||Khurram Nasir|||Zahi Fayad|||Michael V McConnell|||Jamal S Rana|||Rozemarijn Vliegenthart|||David J Maron|||Jagat Narula|||Matthew J Budoff|||Daniel Levy|||Roxana Mehran|||Kim A Williams|||Predimon K Shah|||Oren Mechanic|||Arthur S Agatston|||Robert A Kloner|||Nathan D Wong|||Morteza Naghavi
Journal: European heart journal. Cardiovascular Imaging
Publication Type: Journal Article
Date: 2026
DOI: 10.1093/ehjci/jeag027
ID: 41591983
Affiliations:
Affiliations
HeartLung.AI, Houston, TX, 77021, USA.|||HeartLung.AI, Houston, TX, 77021, USA.|||Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.|||HeartLung.AI, Houston, TX, 77021, USA.|||Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.|||HeartLung.AI, Houston, TX, 77021, USA.|||HeartLung.AI, Houston, TX, 77021, USA.|||HeartLung.AI, Houston, TX, 77021, USA.|||Tustin Teleradiology, Tustin, CA 92780, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Department of Radiology, University of California Irvine, CA 92697, USA.|||Kravis Center for Clinical Cardiovascular Health, Mount Sinai Fuster Heart Hospital, New York, NY 10029 USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Houston Methodist Hospital, Houston, TX 77030, USA.|||BioMedical Engineering and Imaging Institute. Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, 94305, USA.|||Division of Cardiology, Kaiser Permanente Oakland Medical Center, California, USA.|||Department of Radiology, University Medical Center Groningen, GZ 9713, Netherlands.|||Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, 94305, USA.|||University of Houston, Houston, TX, 77030, USA.|||The Lundquist Institute, CA 90502, USA.|||Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20824, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||University of Louisville, Louisville, KY, 40202, USA.|||Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.|||Herbert Wertheim College of Medicine, Department of Emergency Medicine and Critical Care, Miami Beach, Florida; Mount Sinai Medical Center, Department of Emergency Medicine, Miami Beach, Florida.|||Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.|||Huntington Medical Rese Boston Medical Center and Chobanian & Avedisian School of Medicine and School of Public Health, Boston University, Boston, MA 02215, USAarch Institutes, Pasadena, CA, 91105, USA and Keck School of Medicine of University of Southern California, Los Angeles, CA 90033.|||Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, University of California Irvine School of Medicine, CA 92697, USA.|||HeartLung.AI, Houston, TX, 77021, USA.
Abstract
The AI-CVD initiative seeks to extract actionable insights from coronary artery calcium (CAC) scans beyond the traditional CAC score. We previously demonstrated that AI-derived cardiac chamber volumes from CAC scans predict incident heart failure (HF). We aimed to evaluate whether left-to-right cardiac chamber volume ratios outperform chamber volumes in predicting HF.