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AI-Derived LA Volume Index, LA/RA and LA/LV Volume Ratios From Coronary Artery Calcium Scans Predict Long-Term Atrial Fibrillati

Authors: Amir Azimi|||Kyle Atlas|||Anthony P Reeves|||Chenyu Zhang|||Jakob Wasserthal|||Seyed Reza Mirjalili|||Mohammadhossein Mozafarybazargany|||Ali Hashemi|||Thomas Atlas|||Claudia I Henschke|||David F Yankelevitz|||Javier J Zulueta|||Andrea D Branch|||Sion K Roy|||Khurram Nasir|||Sabee Molloi|||Jamal S Rana|||Zahi A Fayad|||Michael V McConnell|||George S Abela|||Rozemarijn Vliegenthart|||David J Maron|||Jagat Narula|||Kim A Williams|||Prediman K Shah|||Matthew J Budoff|||Emelia J Benjamin|||Roxana Mehran|||Robert A Kloner|||Nathan D Wong|||Morteza Naghavi

Journal: Stroke

Publication Type: Journal Article

Date: 2026

DOI: NIHMS2159178

ID: 41948813

Affiliations:

Affiliations

    HeartLung.AI, Houston, TX (A.A., K.A., C.Z., S.R.M., M.M., A.H., M.N.).|||HeartLung.AI, Houston, TX (A.A., K.A., C.Z., S.R.M., M.M., A.H., M.N.).|||Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY (A.P.R.).|||HeartLung.AI, Houston, TX (A.A., K.A., C.Z., S.R.M., M.M., A.H., M.N.).|||Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Switzerland (J.W.).|||HeartLung.AI, Houston, TX (A.A., K.A., C.Z., S.R.M., M.M., A.H., M.N.).|||HeartLung.AI, Houston, TX (A.A., K.A., C.Z., S.R.M., M.M., A.H., M.N.).|||HeartLung.AI, Houston, TX (A.A., K.A., C.Z., S.R.M., M.M., A.H., M.N.).|||Tustin Teleradiology, CA (T.A.).|||Department of Diagnostic, Molecular, and Interventional Radiology (C.I.H., D.F.Y.), Icahn School of Medicine at Mount Sinai, NY.|||Department of Diagnostic, Molecular, and Interventional Radiology (C.I.H., D.F.Y.), Icahn School of Medicine at Mount Sinai, NY.|||Pulmonary, Critical Care and Sleep Medicine, Mount Sinai Morningside Hospital, NY (J.J.Z.).|||Department of Medicine (A.D.B., R.M.), Icahn School of Medicine at Mount Sinai, NY.|||The Lundquist Institute, CA (S.K.R., M.J.B.).|||Houston Methodist Hospital, TX (K.N.).|||Department of Radiology, University of California, Irvine, CA (S.M.).|||Division of Cardiology, Kaiser Permanente Oakland Medical Center, California (J.S.R.).|||BioMedical Engineering and Imaging Institute. Icahn School of Medicine at Mount Sinai, NY (Z.A.F.).|||Stanford Prevention Research Center, Stanford University School of Medicine, CA (M.V.M.C., D.J.M.).|||Division of Cardiology, Michigan State University, East Lansing (G.S.A.).|||Department of Radiology, University Medical Center Groningen, the Netherlands (R.V.).|||Stanford Prevention Research Center, Stanford University School of Medicine, CA (M.V.M.C., D.J.M.).|||University of Houston, TX (J.N.).|||University of Louisville, KY (K.A.W.).|||Cedars-Sinai Medical Center, Los Angeles, CA (P.K.S.).|||The Lundquist Institute, CA (S.K.R., M.J.B.).|||Boston Medical Center and Boston University Chobanian & Avedisian School of Medicine and School of Public Health, MA (E.J.B.).|||Department of Medicine (A.D.B., R.M.), Icahn School of Medicine at Mount Sinai, NY.|||Huntington Medical Research Institutes, Pasadena, CA (R.A.K.).|||Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, University of California, Irvine (N.D.W.).|||HeartLung.AI, Houston, TX (A.A., K.A., C.Z., S.R.M., M.M., A.H., M.N.).

Abstract

The AI-CVD initiative aims to extract actionable insights from coronary artery calcium (CAC) scans beyond the traditional CAC score. Although AI-derived cardiac chamber volumes predict atrial fibrillation (AF) and stroke, the long-term prognostic value of chamber ratios is less established. We evaluated the predictive value of AI-derived left atrial volume index and related chamber ratios (left atrial [LA]/right atrial [RA], LA/left ventricular) from routine CAC scans for incident AF and stroke, and their incremental value beyond established risk scores.


Reference List

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