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Comparing incidence of heart failure in individuals with enlarged cardiac chambers versus diabetes.

Authors: Seyed Reza Mirjalili|||Kyle Atlas|||Anthony P Reeves|||Chenyu Zhang|||Jakob Wasserthal|||Amir Azimi|||Ali Hashemi|||Mohammadhossein Mozafarybazargany|||Amir Ghaffari Jolfayi|||Thomas Atlas|||Claudia I Henschke|||David F Yankelevitz|||Javier J Zulueta|||Jeffrey Mechanick|||Andrea D Branch|||Ning Ma|||Rowena Yip|||Wenjun Fan|||Sion K Roy|||Khurram Nasir|||Sabee Molloi|||Zahi Fayad|||Michael V McConnell|||Ioannis A Kakadiaris|||George Abela|||Rozemarijn Vliegenthart|||David J Maron|||Jagat Narula|||Kim A Williams|||Prediman K Shah|||Matthew J Budoff|||Daniel Levy|||Roxana Mehran|||Robert A Kloner|||Nathan D Wong|||Morteza Naghavi

Journal: American journal of preventive cardiology

Publication Type: Journal Article

Date: 2026

DOI: PMC13329587

ID: 42403463

Affiliations:

Affiliations

    HeartLung.AI, Houston, TX 77021, USA.|||HeartLung.AI, Houston, TX 77021, USA.|||Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.|||HeartLung.AI, Houston, TX 77021, USA.|||University of Basel, Switzerland, Basel 4001, Switzerland.|||HeartLung.AI, Houston, TX 77021, USA.|||HeartLung.AI, Houston, TX 77021, USA.|||HeartLung.AI, Houston, TX 77021, USA.|||HeartLung.AI, Houston, TX 77021, USA.|||Tustin Teleradiology, Tustin, CA 92780, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Kravis Center for Clinical Cardiovascular Health, Mount Sinai Fuster Heart Hospital, New York, NY 10029, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Department of Epidemiology and Biostatistics, Wen School of Public Health, University of California, Irvine, USA.|||The Lundquist Institute, CA 90502, USA.|||Houston Methodist Hospital, Houston, TX 77030, USA.|||Department of Radiology, University of California Irvine, CA 92697, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA.|||Computational Biomedicine Laboratory, Department of Computer Science, University of Houston, Houston, TX, USA.|||Division of Cardiology, Michigan State University, East Lansing, MI 48823, USA.|||Dept of Radiology, University Medical Center Groningen, GZ 9713, the Netherlands.|||Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA.|||University of Houston, Houston, TX 77030, USA.|||University of Louisville, Louisville, KY 40292, USA.|||Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.|||The Lundquist Institute, CA 90502, USA.|||Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20824, USA.|||Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|||Huntington Medical Research Institutes, Pasadena, CA 91105, USA.|||Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, University of California Irvine, CA 92697, USA.|||HeartLung.AI, Houston, TX 77021, USA.

Abstract

Opportunistic cardiac chamber volumetry derived from coronary artery calcium (CAC) scans using the AI-CVD platform predicts heart failure (HF) independent of conventional risk factors. Type 2 diabetes mellitus (T2DM), which classifies individuals as Stage A HF, is associated with chamber enlargement; however, the HF risk associated with chamber enlargement in the absence of T2DM has not been characterized.


Reference List

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